How to check if a word is an English word with Python?

For (much) more power and flexibility, use a dedicated spellchecking library like PyEnchant. There's a tutorial, or you could just dive straight in:

>>> import enchant
>>> d = enchant.Dict("en_US")
>>> d.check("Hello")
True
>>> d.check("Helo")
False
>>> d.suggest("Helo")
['He lo', 'He-lo', 'Hello', 'Helot', 'Help', 'Halo', 'Hell', 'Held', 'Helm', 'Hero', "He'll"]
>>>

PyEnchant comes with a few dictionaries (en_GB, en_US, de_DE, fr_FR), but can use any of the OpenOffice ones if you want more languages.

There appears to be a pluralisation library called inflect, but I've no idea whether it's any good.

It won't work well with WordNet, because WordNet does not contain all english words. Another possibility based on NLTK without enchant is NLTK's words corpus

>>> from nltk.corpus import words
>>> "would" in words.words()
True
>>> "could" in words.words()
True
>>> "should" in words.words()
True
>>> "I" in words.words()
True
>>> "you" in words.words()
True

Using NLTK:

from nltk.corpus import wordnet

if not wordnet.synsets(word_to_test):
  #Not an English Word
else:
  #English Word

You should refer to this article if you have trouble installing wordnet or want to try other approaches.

Using a set to store the word list because looking them up will be faster:

with open("english_words.txt") as word_file:
    english_words = set(word.strip().lower() for word in word_file)

def is_english_word(word):
    return word.lower() in english_words

print is_english_word("ham")  # should be true if you have a good english_words.txt

To answer the second part of the question, the plurals would already be in a good word list, but if you wanted to specifically exclude those from the list for some reason, you could indeed write a function to handle it. But English pluralization rules are tricky enough that I'd just include the plurals in the word list to begin with.

As to where to find English word lists, I found several just by Googling "English word list". Here is one: http://www.sil.org/linguistics/wordlists/english/wordlist/wordsEn.txt You could Google for British or American English if you want specifically one of those dialects.