pandas get rows which are NOT in other dataframe

One method would be to store the result of an inner merge form both dfs, then we can simply select the rows when one column's values are not in this common:

In [119]:

common = df1.merge(df2,on=['col1','col2'])
print(common)
df1[(~df1.col1.isin(common.col1))&(~df1.col2.isin(common.col2))]
   col1  col2
0     1    10
1     2    11
2     3    12
Out[119]:
   col1  col2
3     4    13
4     5    14

EDIT

Another method as you've found is to use isin which will produce NaN rows which you can drop:

In [138]:

df1[~df1.isin(df2)].dropna()
Out[138]:
   col1  col2
3     4    13
4     5    14

However if df2 does not start rows in the same manner then this won't work:

df2 = pd.DataFrame(data = {'col1' : [2, 3,4], 'col2' : [11, 12,13]})

will produce the entire df:

In [140]:

df1[~df1.isin(df2)].dropna()
Out[140]:
   col1  col2
0     1    10
1     2    11
2     3    12
3     4    13
4     5    14

Assuming that the indexes are consistent in the dataframes (not taking into account the actual col values):

df1[~df1.index.isin(df2.index)]

As already hinted at, isin requires columns and indices to be the same for a match. If match should only be on row contents, one way to get the mask for filtering the rows present is to convert the rows to a (Multi)Index:

In [77]: df1 = pandas.DataFrame(data = {'col1' : [1, 2, 3, 4, 5, 3], 'col2' : [10, 11, 12, 13, 14, 10]})
In [78]: df2 = pandas.DataFrame(data = {'col1' : [1, 3, 4], 'col2' : [10, 12, 13]})
In [79]: df1.loc[~df1.set_index(list(df1.columns)).index.isin(df2.set_index(list(df2.columns)).index)]
Out[79]:
   col1  col2
1     2    11
4     5    14
5     3    10

If index should be taken into account, set_index has keyword argument append to append columns to existing index. If columns do not line up, list(df.columns) can be replaced with column specifications to align the data.

pandas.MultiIndex.from_tuples(df<N>.to_records(index = False).tolist())

could alternatively be used to create the indices, though I doubt this is more efficient.

Suppose you have two dataframes, df_1 and df_2 having multiple fields(column_names) and you want to find the only those entries in df_1 that are not in df_2 on the basis of some fields(e.g. fields_x, fields_y), follow the following steps.

Step1.Add a column key1 and key2 to df_1 and df_2 respectively.

Step2.Merge the dataframes as shown below. field_x and field_y are our desired columns.

Step3.Select only those rows from df_1 where key1 is not equal to key2.

Step4.Drop key1 and key2.

This method will solve your problem and works fast even with big data sets. I have tried it for dataframes with more than 1,000,000 rows.

df_1['key1'] = 1
df_2['key2'] = 1
df_1 = pd.merge(df_1, df_2, on=['field_x', 'field_y'], how = 'left')
df_1 = df_1[~(df_1.key2 == df_1.key1)]
df_1 = df_1.drop(['key1','key2'], axis=1)